Technology
QuantuMDx’s Mission
QuantuMDx is developing technologies that address a real market need We’re taking complex molecular analysis and simplifying it for use by health workers from all types of background and healthcare environments. By integrating diagnostics with cell phone technology we’re also able to support health workers in educating their patients at the time of consultation and remotely in their homes and at work.
DNA Extraction
We have created a simple microfluidic solution for DNA extraction that is capable of performing the extraction in under 5 minutes and from most sample sources, including blood, tissue, saliva, sputum and urine. This novel single flow-through solution provides a perfect front-end to molecular assays and devices or integrated within handheld or portable medical devices.
Diagnostic biosensor
Our novel nanowire based biosensor detects the binding of analytes to probes immobilized on the surface of the array of nanowires based upon their electrical charge which means there’s no fluorescence, no optics and no light. The biosensor can detect any analyte be it DNA, RNA, protein or other metabolite and convert it straight into binary code, the universal language of computers. As we use standard CMOS produced computer chips, we’re able to bring the cost of highly complex, time consuming molecular diagnostics into the low price point of routine pathology testing and at the patient’s side.
Genomic sequencing biosensor
Our proprietary genomic sequencing biosensor has been functionalized with our novel chemistries but also works with established sequencing chemistries. The nanowires within the genomic sequencer have been arrayed and functionalized for long reads lengths as well as undertaking shotgun sequencing.
Thermal Reactor
Using a combination of a series of simple microfluidic channels & a complex arrangement of multiple thermal heating elements, QMDx can perform many different and extreme PCR programmes without the need to ramp, thus requiring a single heating step like isothermal methods.
Supercharged Nucleotides
We have created proprietary reagents for our technologies, including Supercharged Nucleotides. These nucleotides can be incorporated into targets during PCR, to amplify the signal on the nanowire biosensors meaning that we need less PCR cycles and therefore produce a faster result.
iApps
With our software partners we have developed a range of mobile apps to support a clinician or health professional to provide their patients with more in-depth, easy to understand information and education about their diagnosis.